Bevacizumab at a dose of 7.5mg/Kg [BEV3]
In combination with 1st line chemotherapy AS INDUCTION TREATMENT for patients with stage III or IV ovarian, fallopian tube or primary peritoneal carcinoma where the following criteria have been met: Note: there is a separate form BEV9 for the use of bevacizumab at a dose of 15mg/Kg in combination with 1st line chemotherapy AS INDUCTION TREATMENT for advanced ovarian cancer Note: there is a separate form BEV10 for the use of bevacizumab monotherapy at dose of 7.5mg/Kg as MAINTENANCE treatment after completion of induction chemotherapy Note: there is a separate form OLAP4 for the use of bevacizumab at a dose of 15mg/kg in combination with olaparib as MAINTENANCE treatment after
- This application is being made by and the first cycle of systemic anti-cancer therapy with bevacizumab in combination with induction chemotherapy will be prescribed by a consultant specialist specifically trained and accredited in the use of systemic anti-cancer therapy.
- Bevacizumab at a dose of 7.5mg/Kg is to be used in combination with 1st line induction chemotherapy for previously untreated advanced epithelial ovarian, fallopian tube or primary peritoneal cancer.
- One of the following criteria applies to this patient: i) FIGO stage III disease and debulked but residual disease more than 1cm or ii) FIGO stage III disease and unsuitable for debulking surgery or iii) FIGO stage IV disease or iv) FIGO stage III disease at presentation and requires neo-adjuvant chemotherapy due to low likelihood of optimal primary surgical cytoreduction
- Bevacizumab is to be given in combination with carboplatin and paclitaxel chemotherapy.
- Bevacizumab is to start with: i) the 1st or 2nd cycle of chemotherapy following primary debulking surgery, or ii) the 1st or 2nd cycle of chemotherapy following interval debulking surgery performed after 3 – 4 cycles of non-bevacizumab-containing neoadjuvant chemotherapy, or iii) the 1st or 2nd cycle of chemotherapy for those patients who have inoperable stage IV disease or inoperable stage III disease or who are unable to undergo surgery due to increased risk during COVID19 or iv) the 1st or 2nd cycle of neo-adjuvant chemotherapy a
- Bevacizumab is to be given at a dose of 7.5mg/Kg every 3 weeks.
- A maximum of 6 cycles of bevacizumab will be given as part of induction chemotherapy.
- As neither this dosage of bevacizumab nor its use in the neoadjuvant setting is licensed in ovarian cancer, this use of bevacizumab must be used within the treating Trust’s governance framework. Note: This policy relating to the use of bevacizumab 7.5mg/Kg is NOT for patients with stage I-III disease who have had optimal debulking
- When a treatment break is needed of more than 6 weeks beyond the expected cycle length of 3-weekly treatment, I will complete a treatment break approval form to restart treatment, including as appropriate if the patient had an extended break on account of Covid-19.
- Bevacizumab is to be otherwise used as set out in its Summary of Product Characteristics.
NHS funded From: 01 April 2021
Additional information
Current Form Version
Note
The data on this page was produced using version 1.361 of the CDF list, downloaded from an archive of NHS England’s website on 08 May 2025 at 22:10.
If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.